L-Lysine-S-Carboxy Methyl-L-Cysteine

Price:

20

Quantity Order:

Origin:

China

Payment Method:

Telegraphic Transfer (T/T)

Quantity:

10000kgs

Pack. & Delivery:

fiber drums

Product name: L-Lysine-S-Carboxy Methyl-L-Cysteine
Synonyme: L-Carbocysteine-Lysine, SCMC-Lys
CAS# : 49673-81-6
Molecular Formula: C6H14N2O2.C5H9NO4S
Specification: 98%
Function:
Carbocysteine lysine salt monohydrate ( SCMC-Lys) is a well-known mucoactive drug whose therapeutic efficacy is commonly related to the ability of SCMC-Lys to replace fucomucins by sialomucins. The aim of this study was to determine if SCMC-Lys couldexert an anti-oxidant action by scavenging reactive oxygen intermediates ( ROIs) . Our results show that SCMC-Lys proved effective as a selective scavenger of hypochlorous acid ( HOCl) and hydroxyl radical ( OH.) , this effect being related to the reactivity of the SCMC tioether group. The scavenger activity of SCMC-Lys was observed in free cellular system as well as in activated human polymorphonuclear neutrophils ( PMNs) . SCMC-Lys scavenger activity on HOCl was paralleled by a powerful protection from HOCl-mediated inactivation ofalpha1-antitripsin ( alpha1-AT) inhibitor, the main serum protease inhibitor. Production of interleukin-( IL-) 8, a major mediator of PMN recruitment in inflammatory diseases, is known to be mediated by intracellular OH.SCMC-Lys significantly reduced IL-8 production on stimulated human peripheral blood mononuclear cells ( PBMCs) in the same range of concentrations affecting OH. activity. It is concluded that SCMC-Lys could exert, in addition to its mucoactive capacity, an anti-oxidant action, thus contributing to the therapeutic efficacy of SCMC-Lys.

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